1. Combining machine learning algorithms and single-cell data to ...
29 jan 2024 · Abstract. Extracting valuable insights from high-throughput biological data of Alzheimer's disease to enhance understanding of its ...
Extracting valuable insights from high-throughput biological data of Alzheimer’s disease to enhance understanding of its pathogenesis is becoming increasingly important. We engaged in a comprehensive collection and assessment of Alzheimer’s microarray datasets GSE5281 and GSE122063 and single-cell data from GSE157827 from the NCBI GEO database. The datasets were selected based on stringent screening criteria: a P-value of less than 0.05 and an absolute log fold change (|logFC|) greater than 1. Our methodology involved utilizing machine learning algorithms, efficiently identified characteristic genes. This was followed by an in-depth immune cell infiltration analysis of these genes, gene set enrichment analysis (GSEA) to elucidate differential pathways, and exploration of regulatory networks. Subsequently, we applied the Connectivity Map (cMap) approach for drug prediction and undertook single-cell expression analysis. The outcomes revealed that the top four characteristic genes, selected based on their accuracy, exhibited a profound correlation with the Alzheimer’s disease (AD) group in terms of immune infiltration levels and pathways. These genes also showed significant associations with multiple AD-related genes, enhancing the potential pathogenic mechanisms through regulatory network analysis and single-cell expression profiling. Identified three subpopulations of astrocytes in late-stage of AD Prefrontal cortex dataset. Discovering dysregulation of the expression of the A...
2. [PDF] 5th T21RS
Anna and John J. Sie Foundation. Page 62. 62. P004. Genome-wide association meta-analysis of Alzheimer's dementia and age-at-onset in adults with Down Syndrome.
3. Mispatterning and interneuron deficit in Tourette Syndrome Basal ... - NCBI
29 nov 2022 · This study uncovers early neurodevelopmental underpinnings of TS neuropathological deficits using organoids as a model system.
Tourette Syndrome (TS) is a neuropsychiatric disorder thought to involve a reduction of basal ganglia (BG) interneurons and malfunctioning of the BG circuitry. However, whether interneurons fail to develop or are lost postnatally remains unknown. To investigate ...
4. Table of Contents — October 28, 2015, 35 (43) | Journal of Neuroscience
28 okt 2015 · Multisensory Integration Reveals Temporal Coding across a Human Sensorimotor Network ... Monika Rataj-Baniowska, Anna Niewiadomska-Cimicka, Marie ...
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5. Retinoid metabolism: new insights in - Journal of Molecular Endocrinology
Here, I will discuss the enzymes that metabolize vitamin A to RA and the cytochrome P450 Cyp26 family of enzymes that further oxidize RA.
Vitamin A (retinol) is a critical micronutrient required for the control of stem cell functions, cell differentiation, and cell metabolism in many different cell types, both during embryogenesis and in the adult organism. However, we must obtain vitamin A from food sources. Thus, the uptake and metabolism of vitamin A by intestinal epithelial cells, the storage of vitamin A in the liver, and the metabolism of vitamin A in target cells to more biologically active metabolites, such as retinoic acid (RA) and 4-oxo-RA, must be precisely regulated. Here, I will discuss the enzymes that metabolize vitamin A to RA and the cytochrome P450 Cyp26 family of enzymes that further oxidize RA. Because much progress has been made in understanding the regulation of ALDH1a2 (RALDH2) actions in the intestine, one focus of this review is on the metabolism of vitamin A in intestinal epithelial cells and dendritic cells. Another focus is on recent data that 4-oxo-RA is a ligand required for the maintenance of hematopoietic stem cell dormancy and the important role of RARβ (RARB) in these stem cells. Despite this progress, many questions remain in this research area, which links vitamin A metabolism to nutrition, immune functions, developmental biology, and nuclear receptor pharmacology.
6. [PDF] Final Degree Project Biomedical Engineernig Degree Leveraging ...
5 jun 2024 · Huntington's disease (HD) is a neurodegenerative disorder characterized by neural loss in specific brain regions, particularly affecting the ...
7. [PDF] Retinoic acid receptor beta protects striatopallidal medium spiny ... - HAL
20 apr 2023 · Retinoic acid is a powerful regulator of brain development, however its postnatal functions only start to be elucidated.
8. [PDF] Hormonal Influence on the Proliferation Potential of C17.2 ...
The brain is arguably the most complex organ of the body: Controlling muscles, maintaining homeostasis, processing information.
9. [PDF] sr_final_baja_3.pdf - CNIC
A research center, like any other institution, needs to rejuvenate its internal organization as it matures. One of the CNIC's great.
10. [PDF] Shaping down syndrome brain cognitive and molecular changes ...
4 mei 2024 · Down syndrome (DS) is the most common condition with intellectual disability and is caused by trisomy of Homo sapiens chromosome 21 (HSA21).
11. Articles | Neural Development - BioMed Central
Neural Development highlights recent advances exploring how the nervous system arises and acquires the abilities to sense the world and control adaptive ...
Neural Development highlights recent advances exploring how the nervous system arises and acquires the abilities to sense the world and control adaptive motor ...
12. [PDF] Genetically- and spatially-defined basolateral amygdala neurons ...
Baniowska et al. 2015). Page 35. 35. For clarity, we unified the naming of cell populations in the diverse conditions as follows: clusters from unsupervised ...